Avamys Nasal Spray Uses, Dosage, Side Effects
Avamys Nasal Spray is a white uniform suspension which contained in an amber glass bottle, and also fitted with a metering atomising spray pump, This inner pack incorporated within a predominantly off-white plastic device with a blue side actutued lever and a lid which contains a stopper. Each Avamys spray of the suspension delivers approximately 27.5 micrograms of micronised Fluticasone Furoate as an ex-device dose.
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Amays Nasal Spray contains Fluticasone Propioriate which is a synthetic corticosteroid with mainly glucocorticocoid activity. Fluticasone Propionate Nasal Spray used by oral inhalation for the prophylactic treatment of asthma. It also reported to have a local effect on lungs without causing significant systemic effects, reduces airway inflammation and hence reduces oedema and scretions of mucous into the airway. It used as a nasal spray in the treatment of allergic rhinitis. When applied topically used in the treatment of various skin disorders.
Avamys Nasal Spray Indications
Adults And Adolescents (12 Years And Older)
Avamys Nasal Spray use for the treatment of the nasal symptoms like:
- rhinorrhea
- Nasal congestion
- Nasal itching
- Sneezing
And ocular symptoms like:
- Itching
- Burning
- Tearing
- Watering
- Redness of the eye
Chilren (2 to 11 years)
Treatment of nasal symptoms like:
- Rhinorrhea
- Nasal Congestion
- Nasal Itching
- Sneezing
Avamys Nasal Spray Dosage And Administraion
Avamys Nasal Spray Dosage administrated by the intranasal route only. For full therapeutic benefit regular scheduled usage is recommended. Onset of action has been observed as early as 8 hours after initial administration. It may take several days of treatment to achieve maximum benefit. An absence of an immediate effect should explained tot he patients.
Fluticasone Furoate Nasal Spray Dosage For Adults And Adolescents (12 Years And Older)
The recommended starting Nasal Spray Dosage is 2 sprays (27.5 micrograms per spray) in each nostril once daily (total daily Fluticasone Furoate Dosage of 110 micrograms). Once adequate control of symptoms achieved, the Fluticasone Furoate Nasal Spray Dosage reduction to 1 spray in each nostril once daily (total daily Fluticasone Furoate Dose of 55 Micrograms) may be effective for maintenance.
Fluticasone Furoate Nasal Spray Dosage For Children (2 to 11 years)
Meanwhile, The recommended starting Fluticasone Furoate Nasal Spray Dosage is 1 spray (27.5 microgram per spray) in each nostril once daily (total Fluticasone Furoate Nasal Spray Daily Dosage 55 micrograms). Patients not adequately responding to 1 spray in each nostril once daily (total daily Fluticasone Furoate Nasal Spray Dose 110 micrograms). Once adequate control of symptoms achieved the Nasal Spray Dose reduction to 1 spray in each nostril once daily recommended.
Nasal Spray For Children (Under 2 Years Of Age)
However, There are no data to recommend use of Avamys Nasal Spray for the treatment of seasonal or perennial allergic rhinitis in children under 2 years of age.
Fluticasone Furoate Nasal Spray Contraindications
Avamys Nasal Spray contraindicated in patients with:
- hypersensitivity to any of the ingredients.
Avamys Warnings And Precautions
Avamys Nasal Spray undergoes extensive first pass metabolism by the liver enzyme CYP3A4. Therefore the pharmacokinetics of intranasal fluticasone furoate in patients with severe liver disease may altered. However, based on data with another glucocorticoid metabolised by CYP3A4, co-administration with ritonavir not recommended because of the potential risk of increased systemic exposure to fluticasone furoate. On the other hand, Systemic effects with nasal corticosteroids have reported. Particularly at high doses prescribed for prolonged periods. However, These effects are much less likely to occur than with oral corticosteroids and may vary in individual patients and between different corticosteroid preparations.
Avamys Drug Interactions
Fluticasone Furoate rapidly cleared by extensive first pass metabolism mediated by the cytochrome P450 3A4. Therefore, In a drug interaction study of intranasal fluticasone furoate with the potent CYP3A4 inhibitor ketoconazole. Meanwhile, there were more subjects with measurable fluticasone furoate plasma concentrations in the keoconazole group 6 out of 20 subjects, compared to placebo 1 of the 20 subjects. However, This small increase in exposure did not result in a statistically significant difference in 24 hour serum cortisol levels between the two groups.
However, The enzyme induction and inhibition data suggest that there is no theoretical basis for anticipating metabolic interactions between fluticasone furoate Nasal Spray. And the cytochrome P450 mediated metabolism of other compounds at clinically relevant intranasal doses. Therefore, no clinical studies have been conducted to investigate interactions of fluticasone furoate on other drugs.
Pregnancy And Lactation
However, adequate data not available regarding the use of Avamys Nasal Spray during pregnancy and lactation in humans. But, Avamys Nasal Spray should use in pregnancy only if the benefits to the mother are more than the potential risks to the foetus. On the other hand, excretion of fluticasone furoate into human breast milk has not investigated.
Effects On Ability To Drive And Use Machines
However, Based on the pharmacology of fluticasone furoate and other intra nasally administered steroids. Therefore no reason to expect and effect on ability to drive or to operate machinery with Avamys Nasal Spray.
Avamys Nasal Spray Side Effects
However, Avamys Nasal Spray is well tolerated but like all the medicine there are some Side Effects also shown of this product.
Respiratory, Thoracic And Mediastinal Disorders
Very Common: Epistaxis
Common: Nasal Ulceration
Immune System Disorders
Rare: Hypersensitivity reactions including, Anaphylaxis, Angioedema, Rash and Urticaria
Respiratory, Thoracic And Mediastinal Disorders
Uncommon: Rhinalgia, Nasal discomfort, Nasal burning, Nasal irritation, Nasal soreness, Nasal dryness
Avamys Nasal Spray Overdose Symptoms And Treatment
In a bio availability study intra nasal doses of Avamys up to 24 times the recommended daily adult dose were studied over three days with no adverse systemic effects observed. Meanwhile, for the treatment in acute overdose is unlikely to require any therapy other than observation.
Nasal Spray Fluticasone Furoate Storage Instructions
Most importantly, store the drug below 30 C temperature. On the other hand, do not refrigerate or freeze the drug. In addition, always remember to store all your medicines out of the reach of your children.
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Avamys (Fluticasone Furoate) Nasal Spray